Multiple epidemiological studies have established and continue to emphasizethe fact that sepsis is the dominant syndrome in modern Intensive CareUnits. Severe sepsis occurs in approximately 50 to 100 cases/100,000 people/year and is the most common cause of death in intensive care patients. Severesepsis and septic shock are now also the most common cause of kidney failurein intensive care and the most common cause of severe kidney failure requiringin general renal replacement therapy. This kind of kidney failure, however, israrely seen in isolation. Most commonly, it occurs as part of a syndrome ofmultiple organ failure, where the kidney is one of several organ systems thatbecome profoundly dysfunctional. In this setting, vasodilatory shock is frequent,mechanical ventilation is frequent and disorders of bone marrow function,acid-base balance, gastrointestinal activity and cerebral function arecommon. Thus, severe sepsis links kidney function, multiple organ function andpatient outcome from the start to the end.
BAJAR ARCHIVO
